For unknown reasons the guardians had a falling out with their employers and were now fugitives on the run. It was later revealed that Scream and her 'siblings' survived, as the Life Foundation was able to save them and their symbiotes. The age-accelerating machine appeared to make the symbiotes age to dust before the Life Foundation blew up the base.

Once Spider-Man helped Eddie Brock escape, Scream and the other guardian symbiotes, Lasher, Phage, Riot and Agony, then tangled with Spider-Man and Venom, but Venom turned an accelerated aging device on the five. Unknown to her, Spider-Man had hitched a ride on that same hovercraft. Quickly bested by the more experienced fighter, Scream escaped in a hovercraft which returned to the Life Foundation's base. During Scream's first public appearance, she encountered Spider-Man while terrorizing a shopping mall near Salinas, California. Carlton Drake was experimenting with symbiotes in the hopes of creating so-called 'super-cops' to watch over the imagined fallout shelter utopia, and Donna was picked from the security force made up of police, soldiers and mercenaries. Donna Diego was a volunteer for the Life Foundation, a survivalist group within the American government preparing both for the mutually assured destruction fallout of the Cold War and to provide a comfortable life for wealthy clients after the impending nuclear holocaust.

The Scream symbiote was one of the five symbiotes that were forcefully spawned from the original Venom symbiote, and was their unofficial Californian leader. Scream first appeared in Venom: Lethal Protector #4 (May 1993), and was created by David Michelinie and Ron Lim. The Scream symbiote has appeared in Spider-Man comics, as one of five symbiote spawns created simultaneously and has had four different types. Scream is a supervillainess and antiheroine appearing in American comic books published by Marvel Comics.

Symbiote's autonomous defense capabilities.

All powers of the predecessor's first human host.

Donna Diego as Scream in Venom: Separation Anxiety #4 (March 1995).

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